For the effective treatment of field* AK...

Short, 2- or 3-day dosing with Picato®†

Not actual patients. Images are representative of patients with actinic keratosis.

Picato® (ingenol mebutate) gel, 0.05% for 2–day dosing on the body, arms, or legs and 0.015% for 3–day dosing on the face or scalp, is a prescription medicine used on the skin to treat actinic keratosis.

In studies with Picato®, results were measured at Week 8 (Day 57).
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Learn more with the Picato® Patient Experience Kit!§

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What is AK?

Your sun damage could be actinic keratosis (AK), treatable skin lesions that may require medical attention.

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How can I treat AK with Picato®?

Picato® is a clinically effective field* AK treatment with just 2 or 3 days of dosing.

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What might I see within hours of applying Picato®?

You may see skin reactions within hours of your first application.

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Important Safety Information

Do not use Picato® gel if you are allergic to ingenol mebutate or any of the ingredients in Picato® gel.

See additional Important Safety Information.

  • *One tube will cover a continuous area of approximately 2x2 inches or 25 cm2.
  • In studies with Picato®, results were measured at Week 8 (Day 57).
  • Certain restrictions apply. For patients with commercial health insurance, this card may reduce out-of-pocket expenses. Must be 18 years of age or older to be eligible. For eligibility requirements and program restrictions, visit the Savings and Support page or call 1-855-242-6936.
  • §The Picato® Patient Experience Kit does not contain Picato® product or samples.

Indication

Picato® (ingenol mebutate) gel, 0.015%, 0.05% is prescription medicine used on the skin to treat actinic keratosis.

Important Safety Information

Do not use Picato® gel if you are allergic to ingenol mebutate or any of the ingredients in Picato® gel.

Eye problems, including severe eye pain, swelling or drooping of your eyelids, corneal burn, redness, swelling and irritation inside the eye, or swelling around your eyes can happen if Picato® gel gets in your eyes. To avoid getting any of the Picato® into or around the eyes, it is important that you wash your hands well with soap and water after applying Picato® gel and be careful to keep Picato® gel on the treated area from coming into contact with your eyes. If you accidentally get Picato® gel in your eyes, flush them with large amounts of water and get medical care as soon as possible.

There have been reports of serious allergic reactions (hives, itching, flushing and swelling of the lips or tongue, trouble breathing or wheezing, chest tightness and dizziness or passing out) in patients using Picato®. The frequency of these events or their relationship, if any, to treatment with Picato® is unknown. If you experience any such symptoms, discontinue Picato® immediately and seek emergency medical help.

For use on the skin only. Picato® can be applied to a contiguous skin area of approximately 25 cm2 (5 cm x 5 cm). Do not use Picato® in, around, or near your eyes, mouth, lips, or vagina.

Reports of hypersensitivity reactions (anaphylaxis and allergic contact dermatitis) and herpes zoster (shingles) have been received during post approval use of Picato®.

Severe skin reactions in the treated areas on the face/scalp and body/arms/legs, including redness, flaking or scaling, crusting, swelling, blisters, pus, ulcers or breakdown of your skin can happen after applying Picato®. You may also see changes in your skin color (pigmentation changes) and scarring where Picato® gel is applied. You should not use Picato® gel until your skin has healed from other treatments or surgeries. The most common side effects with Picato® gel on the face and scalp (≥2%) include skin reactions in the treatment area (94%), pain at the treatment area (15%), itching at the treatment area (8%), infection at the treatment area (3%), swelling around your eyelids (3%), and headache (2%). The most common side effects with Picato® gel on the body, arms and legs (≥2%) include skin reactions in the treatment area (92%), itching at the treatment area (8%), skin irritation at the treatment area (4%), nose and throat irritation (2%), and pain at the treatment area (2%).

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Picato® gel can harm your unborn baby.

It is also not known if Picato® is safe and effective for the treatment of actinic keratosis in children less than 18 years of age.

You may report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/Safety/MedWatch.

You may also report side effects to LEO Pharma Inc. at 1-877-494-4536, option 1, or email to usdrugsafety@leo-pharma.com.

Please see Picato® Full Prescribing Information.

Eligibility criteria: 1. This card is good for use only with a valid prescription for Picato®. 2. This card is valid for up to 12 ‭prescription fills per calendar year for Picato®. 3. For patients with commercial health insurance, this card may reduce out-of-pocket expenses. 4. Offer good only in the USA at participating retail pharmacies. 5. Original card must be presented to the pharmacist ‭at the time the prescription is filled. Not valid if reproduced. 6. Only one card per patient. 7. The selling, purchasing, trading, or counterfeiting of this card is prohibited by law. 8. Card is not transferable. 9. You must be 18 years of age or older to use this card with your Picato® prescription. 10. This card is not health ‭insurance. 11. You are responsible for the use of this card and ‭for complying with reporting obligations, if any, of your insurance plan. 12. You may not use this card if you are enrolled in any state or federal healthcare program, including Medicaid, Medicare ‭(including Medicare Part D), Medigap, VA, DoD, TRICARE or Chip, unless not eligible for drug coverage in whole or in part. 13. Offer ‭void where prohibited by law, taxed, or restricted. 14. Not valid ‭in combination with any other offers, discounts, or programs. 15. Card has no cash value. 16. LEO Pharma Inc. reserves the right to rescind, revoke, or amend this offer without notice. ‭ 17. You understand and agree to the terms and conditions as set forth above. Full details of the LEO Franchise Card Program may be obtained by calling 1-855-820-9627 (Monday - Friday, 8:00 ‭AM‭-8:00 ‭PM ET) or visiting www.activatethecard.com/LEO.

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